Testing the Statistics on the Distribution of CCR5∆32;

Testing the Statistics on the Distribution of CCR5∆32;
using a typical college classroom as a novel population

victimize:

Homozygous individuals who possess a 32 base bridge deletion (∆32) in the CC-chemokine sense organ CCR-5 divisor gestate been shown to have increased resistance to HIV-1. The present experiment was under(a)taken in prep atomic number 18 to study the presence of the deletion in a model population of 12 Caucasian individuals. Based on precedent literature it is hypothesized that 2.4 out of the twelve individuals will exhibit the mutation. The desoxyribonucleic acid was collected, amplified using PCR, separated using gel electrophoresis, and visualized under UV light. The results of the experiment were inconclusive therefore the hypothesis bleak n each be supported nor rejected. It is believed that the DNA was lost either through purification or the digest.

Introduction:
Members of the chemokine receptor gene family recently have been identified as the co-receptors which allow debut of human immunodeficiency virus type 1 (HIV-1) into human CD4-positive cells.1 The chemokine receptors be members of a superfamily of seven transmembrane loops and transduce their signals through heterotrimeric G-proteins.



2 These receptors can be classified as either CXC- (or [alpha]-) or CC- (or [beta]-) chemokine receptors, according to the unproblematic structure of their natural agonists.3 As can be seen at a lower place in figure 1, there are three types of chemokine receptors that are grouped as specific (bind only one cognize ligand - e.g., CXCR1/IL8RA and CXCR4/fusin/LESTR), shared (CXCR2/IL8RB, CXCR3, CCCR1-CCCR5), promiscuous (bind to many chemokine ligands of either CXC or CC types - e.g. Duffy blood group antigen), and viral (shared receptors that have been transduced into viral genomes during organic evolution - herpes saimiri virus and cytomegalovirus).2

The CCR-5 gene which is located in the p21.3 region of the human chromosome three along with other CC-chemokine receptor genes1, has been...If you want to get a full essay, order it on our website: Orderessay



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