Benzocaine Synthesis

Introduction:
Naturally occu work party local anesthetics have been used for all over a century to dull or alleviate the wound
involved with medical procedures. Specifically, the extract of coca leaves was the first to be used.
Its active ingredient, cocaine, was an effective anesthetic, but its addictive t demiseencies caused it to
be decrepit as an anesthetic and outlawed as a drug. With their greater effectiveness and
decreased side effects, synthetic anesthetics have follow into common use. Essential to the
effectiveness of many of these anesthetics is the aromatic ring at unrivalled end and possibly a standby
or tertiary amine at the other end of the molecule, seperated by a one- to four-unit hydrocarbon
chain.
In this experiment, we will synthesize benzocaine, one of the simpler local anesthetics,
from para-amino benzoic acid and ethanol in the bearing of conc. sulfuric acid. Benzocaine is an
odorless, white, rhombohedric crystal with low water solubility. It is peeled to light exposure
and to temperatures above 30° C. As a drug, it has a low potency and low systemic toxicity. It is
as well as a possible sulfonamide antagonist.
Experimental:
1.20 g of p-amino benzoic acid and 12.0 mL of ethanol were added to a round-bottom flaskful with a
magnetic stirbar. The classification was left to stir until the firm dissolved.



1.0 mL of conc. sulfuric
acid was slowly added and the mixture was allowed to genly travail under reflux for about 75
minutes.
After reaction, the mixture was allowed to cool and was transferred to a beaker containing
30 mL of water. 10% sodium carbonate solution was added until gas was no longer evolved and
the pH was around 8.
The benzocaine was collected using vacuum filtration and was rinsed with water. The
growth was allowed to air dry overnight. An infared spectrum in NUJOL was obtained, and the
NMR spectrum in CDCl3 was run.
give MW mass (g) vol (mL) d (g/mL) m. p. (° C) mol
p-amino benzoic acid 137.14 1.2 - 1.374 188 -189...If you want to abbreviate a full essay, order it on our website: Orderessay



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